Abstract
Inflammation is an inevitable problem associated with the use of bone-implant materials. In this study, naproxen sodium-loaded layered double hydroxides (LDH) capsules were incorporated in situ into a plasma electrolytic oxidation (PEO) coating on an AZ31 Mg alloy to alleviate the inflammatory response. The results indicated that the LDHs were embedded throughout the coating formation process which reinforced the barrier properties of the PEO layer. The coating showed good antibacterial properties and excellent cell adhesion, proliferation, and differentiation abilities. An in situ drug-loaded coating with considerable corrosion resistance and long-term antibacterial effects is suggested for use in biodegradable Mg alloys.
DOI Link to Publication