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journal article

Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines

Abstract

Findings: Molar drug encapsulation efficiency was optimised to be >70%. A non-covalent interaction between the π system and the carboxylate moiety belonging to MTX and the charged aminic group of one of the thiols was found. The MTX loading slightly decreased the structural order of the system and increased the distance between the AuNPs. Free AuNPs showed no cytotoxicity whereas the AuNPs-MTX nanoconjugate had a more potent effect when compared to free MTX. The active role of AuNPs was evidenced by permeation studies: an improvement on penetration of the drug inside cells was evidenced.
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  • URL: https://publications.hereon.de/id/51631/
  • Authors:Salamone, T.A., Rutigliano, L., Pennacchi, B., Cerra, S., Matassa, R., Nottola, S., Sciubba, F., Battocchio, C., Marsotto, M., Del Giudice, A., Chumakov, A., Davydok, A., Grigorian, S., Canettieri, G., Agostinelli, E., Fratoddi, I.
  • Year:2023
  • In: Journal of Colloid and Interface Science
  • Volume:649
  • Pages:264-278
  • Publisher:Elsevier, Orlando
  • Type:journal article
  • ISSN: 0021-9797
  • Cite as: Salamone, T.; Rutigliano, L.; Pennacchi, B.; Cerra, S.; Matassa, R.; Nottola, S.; Sciubba, F.; Battocchio, C.; Marsotto, M.; Del Giudice, A.; Chumakov, A.; Davydok, A.; Grigorian, S.; Canettieri, G.; Agostinelli, E.; Fratoddi, I.: Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines. Journal of Colloid and Interface Science. 2023. vol. 649, 264-278. DOI: doi.org/10.1016/j.jcis.2023.06.078
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