Functionalization of Polycarbonate Surfaces by Grafting PEG and Zwitterionic Polymers with a Multicomb Structure

Yang, J.; Lv, J.; Behl, M.; Lendlein, A.; Yang, D.; Zhang, L.; Shi, C.; Guo, J.; Feng, Y.

Journalpaper

Functionalization of Polycarbonate Surfaces by Grafting PEG and Zwitterionic Polymers with a Multicomb Structure

Abstract

The hemocompatibility of polycarbonateurethane (PCU) surfaces is improved by decoration with poly(poly(ethylene glycol) methacrylate) (poly(PEGMA)) and zwitterionic poly(3-((2-(methacryloyloxy)ethyl)dimethylammonio)propane-1-sulfonate) (poly(DMAPS)) blocks providing a novel multicomb structure obtained by application of surface-initiated atom transfer radical polymerization (s-ATRP) conditions. The PCU-poly(PEGMA-g-DMAPS) surface shows high hydrophilicity with a low contact angle of 20.6 ± 1.8°, while PCU-poly(PEGMA-b-DMAPS) surface exhibitsed a contact angle of 30.5 ± 2.6°. Furthermore, PCU-poly(PEGMA-g-DMAPS) surface shows very low platelet adsorption indicating that multicomb structure modified PCUs are preferred candidate materials for blood-contacting materials.

DOI Link to Publication

URL: https://publications.hereon.de/id/50389/
Authors:Yang, J., Lv, J., Behl, M., Lendlein, A., Yang, D., Zhang, L., Shi, C., Guo, J., Feng, Y.
Year:2013
In: Macromolecular Bioscience
Volume:13
Issue:12
Pages:1681 - 1688
Publisher:Wiley, Weinheim
Type:Journalpaper
ISSN: 1616-5187
Cite as: Yang, J.; Lv, J.; Behl, M.; Lendlein, A.; Yang, D.; Zhang, L.; Shi, C.; Guo, J.; Feng, Y.: Functionalization of Polycarbonate Surfaces by Grafting PEG and Zwitterionic Polymers with a Multicomb Structure. In: Macromolecular Bioscience. Vol. 13 (2013) 12, 1681 - 1688. (DOI: /10.1002/mabi.201300264)