Abstract A Ti-15Mo/TiB metal–matrix composite was produced by spark plasma sintering at 1400 °C. The fractions of the elements in the initial powder mixture were 80.75 wt.% Ti, 14.25 wt.% Mo, and 5 wt.% TiB2. The initial structure of the synthesized composite was composed of bcc β titanium matrix and needle-like TiB reinforcements with an average thickness of 500 ± 300 nm. Microstructure and mechanical properties of the composite were studied after laser beam welding (LBW) was carried out at room temperature or various pre-heating temperatures: 200, 400, or 600 °C. The quality of laser beam welded joints was not found to be dependent noticeably on the pre-heating temperature; all welds consisted of pores the size of which reached 200–300 µm. In contrast to acicular individual particles in the base material, TiB whiskers in the weld zone were found to have a form of bunches. The maximum microhardness in the weld zone (~700 HV) was obtained after welding at room temperature or at 200 °C; this value was ~200 HV higher than that in the base material.