Translocation and release of Von Willebrand factor in the adherent platelet


The adsorption of proteins from blood plasma, molecules secreted by blood cells - such as the activated platelet - participates in orchestrating the overall hemocompatibility of cardiovascular implants. Here, we studied the translocation and secretion of von Willebrand factor (VWF) from human platelets on implant materials using three-dimensional super resolution microscopy in order to explore how local secretion processes can influence thrombotic processes. We hypothesize that beyond the secretion of VWF from the platelet granula, also not secreted VWF might be available on blood contacting implant surfaces after the full activation of the adherent platelet.
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