AbstractHydroxyapatite coatings are biocompatible, osteoconductive and create a corrosion resistance surface on magnesium-based implants. Thermal decomposition of HA during thermal spraying limits its application. To overcome the challenges associated with thermal decomposition of HA during thermal spraying, high velocity oxygen fuel spraying with a good thermal stability for HA is proposed. In this work, the traditional flame spraying was compared to high velocity oxy-fuel (HVOF) for HA depositions on magnesium alloy substrates. The effect of process on microstructure, morphology, corrosion behavior and cellular response of HA layers were evaluated. X-ray diffraction analysis showed that the amount of secondary phases in the HVOF deposited sample was less than that in the flame sprayed coatings. Elemental weight percentage of calcium in corroded surfaces was 21% and 34.5% for HVOF and flame sprayed coatings, respectively. Contrary to the results of the electrochemical impedance spectroscopy measurements for HVOF coating performed during the early hours of immersion in the simulated body fluid (SBF), flame sprayed coating exhibited lower corrosion rate after 5 h immersion in SBF solution.