AbstractThis paper attempts to provide an empirical application of the enhanced Regional Tourism Sustainable Adaptation Framework using a case study of Mombasa Kenya. Climate variability is a challenge to tourism destinations, especially coastal and Island destinations, categories under which Mombasa, our study site falls under. Mombasa has limited capacity to adapt to climate change considering its socio economic conditions and weak institutions, thus making it necessary to explore the possible sustainable pathways for the city using the enhanced Regional Tourism Sustainable Adaptation Framework. Earlier frameworks for tourism adaptation to climate change lacked focus on regional dynamics as well as sustainability aspects, and their implementation pose the risk of mal adaptation to some extent. Using secondary data and data from interviews with tourism stakeholders in Mombasa, the enhanced Regional Tourism Sustainable Adaptation Framework guides our assessment of vulnerability and resilience of the destination, as well as identification of region specific adaptation options for the city within the context of sustainable practice. Based on climate change perceived impacts, risks and vulnerability various adaptation options are presented and discussed as provided in literature. The usefulness of the framework in guiding regional tourism destination managers and policy makers in their pursuit for a regional adaptation options within the tourism sector in order to reduce destinations vulnerability, increase resilience and take advantage of opportunities presented by climate change is underscored.