Abstract
Nanogels (or nano-sized hydrogels) have been extensively investigated as an effective drug delivery system due to their various advantageous properties. Among them, stimuli responsive ‘smart’ nanogels, which have the ability to respond to various external stimuli, such as pH, redox, temperature, enzymes, and light, are the most attractive in the area of controlled anti-cancer drug delivery. In this book chapter, we review and discuss recent progress in the synthesis and applications of polymer-based stimuli-responsive nanogels for anti-cancer therapy and their future prospects.