Destroying activity of magnetoferritin on lysozyme amyloid fibrils

Kopcansky, P.; Siposova, K.; Melnikova, L.; Bednarikova, Z.; Timko, M.; Mitroova, Z.; Antosova, A.; Haramus, V.M.; Petrenko, V.I.; Avdeev, M.V.; Gazova, Z.

Journalpaper

Destroying activity of magnetoferritin on lysozyme amyloid fibrils

Abstract

Presence of protein amyloid aggregates (oligomers, protofilaments, fibrils) is associated with many diseases as diabetes mellitus or Alzheimer's disease. The interaction between lysozyme amyloid fibrils and magnetoferritin loaded with different amount of iron atoms (168 or 532 atoms) has been investigated by small-angle X-rays scattering and thioflavin T fluorescence measurements. Results suggest that magnetoferritin caused an iron atom-concentration dependent reduction of lysozyme fibril size.

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URL: https://publications.hereon.de/id/32556/
Authors:Kopcansky, P., Siposova, K., Melnikova, L., Bednarikova, Z., Timko, M., Mitroova, Z., Antosova, A., Haramus, V.M., Petrenko, V.I., Avdeev, M.V., Gazova, Z.
Year:2015
In: Journal of Magnetism and Magnetic Materials
Volume:377
Pages:267 - 271
Publisher:Elsevier
Type:Journalpaper
ISSN: 0304-8853
Cite as: Kopcansky, P.; Siposova, K.; Melnikova, L.; Bednarikova, Z.; Timko, M.; Mitroova, Z.; Antosova, A.; Haramus, V.M.; Petrenko, V.I.; Avdeev, M.V.; Gazova, Z.: Destroying activity of magnetoferritin on lysozyme amyloid fibrils. In: Journal of Magnetism and Magnetic Materials. Vol. 377 (2015) 267 - 271. (DOI: 10.1016/j.jmmm.2014.10.017)