High Throughput Characterization of Polymer Libraries by Diffuse Reflectance Infrared Spectroscopy


Diffuse reflectance FTIR (DRIFT) was established as a high throughput characterization method for classic copolymer systems. Four different methyl methacrylate-based polymer libraries with styrene, N-vinylpyrrolidone, 4-vinylpyridine, or 2-carboxyethyl acrylate as comonomers were synthesized using an automated/robotic synthesizer platform, and analyzed by 1H NMR and DRIFT. By multivariate data analysis both data sets were compared and correlations with R2 between 0.9373 and 0.9971 could be achieved. By this means high throughput screening of comonomer contents of these polymer libraries was enabled.
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