journal article

Positively Charged Thermoresponsive Nanogels for Anticancer Drug Delivery

Abstract

Thermoresponsive nanogels (NGs) are often used as smart nanocarriers for delivering bioactive molecules. Copolymerization of monomers with different functionalities is a well-known technique that enables the tuning of their properties. Here, the synthesis of positively charged thermoresponsive NGs is reported, based on (N-isopropylacrylamide) (NIPAM) as a thermoresponsive monomer, 2-dimethyl(aminoethyl) methacrylate (DMAEM) as a charged comonomer, and dendritic acrylated polyglycerol (dPG) as a macro-crosslinker. The NGs are characterized in terms of size, Z potential, and transition temperature. In order to evaluate its potential for anticancer therapy, the encapsulation and release of anticancer drugs such as doxorubicin (DOXO) and methotrexate (MTX) are tested. A high drug loading capacity and release rate make these NGs promising nanocarriers for biomedical applications.
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