Abstract
Phosphorylcholine glyceraldehyde (PCGA), the aldehyde derivative of L-α-glycerylphosphorylcholine (GPC), was covalently linked onto polycarbonateurethane (PCU) surface in order to introduce biomimetic structure on its surface. PCGA was grafted onto PCU surface via three coupling reactions on PCU surface using hexamethylene diisocyanate (HDI) and tris(2-aminoethyl)amine (TAEA) as spacers. X-ray photoelectron spectroscopy (XPS), fourier transform infrared (FTIR) spectroscopy and water contact angle measurements verified that PCGA had already been grafted onto PCU surfaces. In addition, surface morphology of PCGA grafted PCU film was observed using atomic force microscope (AFM), which showed that the grafted film has a pin-hole free surface which is rougher than the surface of blank PCU film. Scanning electron microscope (SEM) observation of the modified PCU films after treated with platelet-rich plasma demonstrated that much fewer platelets adhered to the surfaces of the grafted PCU films than to the surface of blank PCU film. The result suggested that these PCGA grafted polymers may have potential application as biomaterials for vascular grafts and some subcutaneously implanted devices.
DOI Link to Publication