Synthesis and Characterization of a Telechelic Peptide as a Precursor for Supramolecular Networks


A peptide showing propensity for the adoption of β-sheet conformation was synthesized in order to develop a defined molecular building block as part of a toolbox for the development of polymer networks based on supramolecular interactions. The peptide was synthesized by microwave-assisted solid phase peptide synthesis and the purification was performed by Reversed Phase-High Performance Liquid Chromatography (RP-HPLC), from which a purity higher than 95 mol-% was obtained. The calculated mass was confirmed by Matrix Assisted Laser Desorption Ionization-Time of Flight-Mass Spectrometry (MALDI-ToF-MS). Further characterization of the peptide was performed by IR and 2D TOCSY, NOESY, and HSQC NMR spectroscopy, which confirmed the identity and the sequence of the peptide.
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