AbstractModern concepts for biofunctional implants often comprise the controlled release of bioactive compounds to gain specific biofunctionalities. Here, amorphous and semi-crystalline copolyester-based shape-memory polymer (SMP) networks are reported as matrix for pharmaceutical applications. Drug loading of such crosslinked networks by swelling techniques requires tools to determine the actual payload. In this report, the capability of determining loading kinetics by mass increase or changes of drug concentration in the swelling medium is explored for two types of copolyester-based SMP networks differing in their crosslinking chemistry. Nitrofurantoin and ethacridine lactate served as hydrophobic and hydrophilic model drugs. It was found, that the absolute values of the determined payload did not systematically agree with those obtained by the more reliable technique of network cleavage and spectrophotometric quantification. However, the studies indicate that for both types of SMP materials and both drugs, maximum incorporation of the drugs occurred within a few hours. The time until equilibration depended on the network properties.