Phospholipids as implant coatings

Willumeit, R.; Schuster, A.; Iliev, P.; Linser, S.; Feyerabend, F.

Journalpaper

Phospholipids as implant coatings

Abstract

Bio-interfaces such as bio-membranes are of out-most importance for a variety of live processes. Among them are cell-interactions which take place in, on or through cell membranes. Therefore we propose to cover metallic surfaces with phospholipids to facilitate cell-material interaction. Four lipids, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-choline (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phos-phoethanolamine (POPE), 1-palmitoyl-2- oleoyl-sn-glycero- 3-[phospho-L-serine] (POPS) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-(1-glycerol) (POPG), were applied to four metallic growth substrates with different surface structure, roughness and porosity. The interaction of the os- teosarcoma cell line MG-63 was investigated in terms of cell adhesion and viability (MTT (methylthiazolyldiphenyl- tetrazolium bromide) assay).

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URL: https://publications.hereon.de/id/25146/
Authors:Willumeit, R., Schuster, A., Iliev, P., Linser, S., Feyerabend, F.
Year:2007
In: Journal of Materials Science: Materials in Medicine
Volume:18
Pages:367 - 380
Publisher:Springer, Netherlands
Type:Journalpaper
ISSN: 0957-4530
Cite as: Willumeit, R.; Schuster, A.; Iliev, P.; Linser, S.; Feyerabend, F.: Phospholipids as implant coatings. In: Journal of Materials Science: Materials in Medicine. Vol. 18 (2007) 367 - 380. (DOI: 10.1007/s10856-006-0702-9)