AbstractThe use of metal implants is appropriate for a broad range of applications in bone repair or substitution. For a better acceptance of the implant, coating of the implant surface is one of the main interests in current research. One approach is the covering of the metal surface by phospholipids lipids (e.g. POPE) leading for example to an increase in chondroitin sulphate production by 30% for Human Articular Chondrocytes (HAC). Still a variety of other lipids is available for implant modification. Their effect on MG-63 cells, gram positive/negative bacteria and macrophages is evaluated.