%0 Artikel
%@ 0168-3659
%A Wischke, C.
%A  Neffe, A.T.
%A  Hanh, B.D.
%A  Kreiner, C.F.
%A  Sternberg, K.
%A  Stachs, O.
%A  Guthoff, R.F.
%A  Lendlein, A.

%D 2013
%J Journal of Controlled Release
%N 2249
%P 1002 - 1010 
%R doi:10.1016/j.jconrel.2013.10.021
%T A multifunctional bilayered microstent as glaucoma drainage device
%U https://dx.doi.org/10.1016/j.jconrel.2013.10.021
3 
%X Commercial non-degradable glaucoma implants are often associated with undesired hypotony, fibrosis, long term failure, and damage of adjacent tissues, which may be overcome by a multifunctional polymeric microstent for suprachoroidal drainage. This study reports the design and fabrication of such devices with tailorable internal diameters (50–300 μm) by solvent-free, continuous hot melt extrusion from blends of poly[(ε-caprolactone)-co-glycolide] and poly(ε-caprolactone) [PCL]. A spatially directed release was supported by bilayered microstents with an internal drug-free PCL layer, and a quantitative description of release kinetics with diclofenac sodium as model drug was provided. Furthermore, the slow degradation pattern (> 1 year) was analyzed and potential effects of 1–5 wt.% drug loading on material properties were excluded. Translational aspects including sterilization by γ-irradiation on dry ice, in vitro biocompatibility, and in vivo implantation were addressed. The promising results support further functional analysis of long-term in vivo performance and suppression of disadvantageous capsule formation.