@article{wischke_a_multifunctional_2013, 
author={Wischke, C. and Neffe, A.T. and Hanh, B.D. and Kreiner, C.F. and Sternberg, K. and Stachs, O. and Guthoff, R.F. and Lendlein, A.},
title={A multifunctional bilayered microstent as glaucoma drainage device},
year={2013},
journal = {Journal of Controlled Release},
volume = {172},
number = {3},
pages = {1002 - 1010},
doi = {10.1016/j.jconrel.2013.10.021},
abstract = {Commercial non-degradable glaucoma implants are often associated with undesired hypotony, fibrosis, long term failure, and damage of adjacent tissues, which may be overcome by a multifunctional polymeric microstent for suprachoroidal drainage. This study reports the design and fabrication of such devices with tailorable internal diameters (50–300 μm) by solvent-free, continuous hot melt extrusion from blends of poly[(ε-caprolactone)-co-glycolide] and poly(ε-caprolactone) [PCL]. A spatially directed release was supported by bilayered microstents with an internal drug-free PCL layer, and a quantitative description of release kinetics with diclofenac sodium as model drug was provided. Furthermore, the slow degradation pattern (> 1 year) was analyzed and potential effects of 1–5 wt.% drug loading on material properties were excluded. Translational aspects including sterilization by γ-irradiation on dry ice, in vitro biocompatibility, and in vivo implantation were addressed. The promising results support further functional analysis of long-term in vivo performance and suppression of disadvantageous capsule formation.},
note = {Online available at: \url{https://dx.doi.org/10.1016/j.jconrel.2013.10.021} (DOI). Wischke, C.; Neffe, A.T.; Hanh, B.D.; Kreiner, C.F.; Sternberg, K.; Stachs, O.; Guthoff, R.F.; Lendlein, A.: A multifunctional bilayered microstent as glaucoma drainage device. In: Journal of Controlled Release. Vol. 172 (2013) 3, 1002 - 1010. (DOI:  /10.1016/j.jconrel.2013.10.021)}}