@misc{moradian_codelivery_of_2022, 
author={Moradian, H., Gossen, M., Lendlein, A.},
title={Co-delivery of genes can be confounded by bicistronic vector design},
year={2022},
howpublished = {journal article},
doi = {https://doi.org/10.1557/s43579-021-00128-7},
abstract = {Maximizing the efficiency of nanocarrier-mediated co-delivery of genes for co-expression in the same cell is critical for many applications. Strategies to maximize co-delivery of nucleic acids (NA) focused largely on carrier systems, with little attention towards payload composition itself. Here, we investigated the effects of different payload designs: co-delivery of two individual “monocistronic” NAs versus a single bicistronic NA comprising two genes separated by a 2A self-cleavage site. Unexpectedly, co-delivery via the monocistronic design resulted in a higher percentage of co-expressing cells, while predictive co-expression via the bicistronic design remained elusive. Our results will aid the application-dependent selection of the optimal methodology for co-delivery of genes.},
note = {Online available at: \url{https://doi.org/10.1557/s43579-021-00128-7} (DOI). Moradian, H.; Gossen, M.; Lendlein, A.: Co-delivery of genes can be confounded by bicistronic vector design. MRS Communications. 2022. vol. 12, 145-153. DOI: 10.1557/s43579-021-00128-7}}