@misc{lau_establishment_of_2021, 
author={Lau, S., Liu, Y., Maier, A., Braune, S., Gossen, M., Neffe, A., Lendlein, A.},
title={Establishment of an in vitro thrombogenicity test system with cyclic olefin copolymer substrate for endothelial layer formation},
year={2021},
howpublished = {journal article},
doi = {https://doi.org/10.1557/s43579-021-00072-6},
abstract = {In vitro thrombogenicity test systems require co-cultivation of endothelial cells and platelets under blood flow-like conditions. Here, a commercially available perfusion system is explored using plasma-treated cyclic olefin copolymer (COC) as a substrate for the endothelial cell layer. COC was characterized prior to endothelialization and co-cultivation with platelets under static or flow conditions. COC exhibits a low roughness and a moderate hydrophilicity. Flow promoted endothelial cell growth and prevented platelet adherence. These findings show the suitability of COC as substrate and the importance of blood flow-like conditions for the assessment of the thrombogenic risk of drugs or cardiovascular implant materials.},
note = {Online available at: \url{https://doi.org/10.1557/s43579-021-00072-6} (DOI). Lau, S.; Liu, Y.; Maier, A.; Braune, S.; Gossen, M.; Neffe, A.; Lendlein, A.: Establishment of an in vitro thrombogenicity test system with cyclic olefin copolymer substrate for endothelial layer formation. MRS Communications. 2021. vol. 11, no. 5, 559-567. DOI: 10.1557/s43579-021-00072-6}}