%0 doctoral thesis
%@ 
%A Behr, S.

%D 2020
%J 

 

%T Impact of magnesium based degradable alloys on a coculture model of osteoblast and osteoclast
%U 
 
%X IV In addition, Mg-Pure and magnesium-silver alloys have also been shown to interact with the calcium  sensing  receptor.  This  interaction  led  to  an  inhibition  of  the  receptor  signal.  Nevertheless, a positive effect on bone formation of both magnesium and silver ions remained, indicating  other  implicated  pathways.  Indeed,  magnesium  positively  influenced  bone  growth  via the  transient  receptor  potential  cation  channel  7  /  phosphoinositide  3-kinase  pathway.  Furthermore, silver via the increased formation of reactive oxygen species supported alkaline phosphatase expression. Finally, a combination of the three materials magnesium, silver and gadolinium could be useful to combine their positive properties.