%0 journal article
%@ 1742-7061
%A Myrissa, A., Braeuer, S., Martinelli, E., Willumeit-Roemer, R., Goessler, W., Weinberg, A.M.

%D 2017
%J Acta Biomaterialia

%P 521-529 
%R doi:10.1016/j.actbio.2016.11.024
%T Gadolinium accumulation in organs of Sprague–Dawley® rats after implantation of a biodegradable magnesium-gadolinium alloy
%U https://doi.org/10.1016/j.actbio.2016.11.024
 
%X In the last years, biodegradable Mg alloys are under investigation due to their promising properties as orthopaedic devices used for bone fracture stabilization. Gadolinium as Rare Earth Element enhances the mechanical properties of Mg-Gd alloys but its toxicity in humans is still questionable. Up to now, there is no study investigating the elements’ metabolism of a REE-containing Magnesium alloy in an animal model. In this study, we examined the gadolinium distribution and accumulation in rat organs during the degradation of Mg10Gd. Our findings showed that Gd is accumulating in the animal organs, especially in spleen, liver and kidney. This study is of crucial benefit regarding a safe application of REE-containing Magnesium alloys in humans.