@misc{miceli_understanding_the_2018, author={Miceli, E., Kuropka, B., Rosenauer, C., Osorio Blanco, E.R., Theune, L.E., Kar, M., Weise, C., Morsbach, S., freund, C., Calderon, M.}, title={Understanding the elusive protein corona of thermoresponsive nanogels}, year={2018}, howpublished = {journal article}, doi = {https://doi.org/10.2217/nnm-2018-0217}, abstract = {Aim: We analyzed the protein corona of thermoresponsive, poly(N-isopropylacrylamide)- or poly(N-isopropylmethacrylamide)-based nanogels. Materials & methods: Traces of protein corona detected after incubation in human serum were characterized by proteomics and dynamic light scattering in undiluted serum. Results: Apolipoprotein B-100 and albumin were the main components of the protein coronae. For dendritic polyglycerol-poly(N-isopropylacrylamide) nanogels at 37°C, an increase in adsorbed immunoglobulin light chains was detected, followed by partially reversible nanogel aggregation. All nanogels in their hydrophilic state are colloidally stable in serum and bear a dysopsonin-rich protein corona. Conclusion: We observed strong changes in NG stability upon slight alterations in the composition of the protein coronae according to nanogel solvation state. Nanogels in their hydrophilic state possess safe protein coronae.}, note = {Online available at: \url{https://doi.org/10.2217/nnm-2018-0217} (DOI). Miceli, E.; Kuropka, B.; Rosenauer, C.; Osorio Blanco, E.; Theune, L.; Kar, M.; Weise, C.; Morsbach, S.; freund, C.; Calderon, M.: Understanding the elusive protein corona of thermoresponsive nanogels. Nanomedicine. 2018. vol. 13, no. 20, 217. DOI: 10.2217/nnm-2018-0217}}