@misc{lamby_effect_of_2017, author={Lamby, P., Jung, F., Graf, S., Schellenberg, L., Falter, J., Platz-da-Silva, N., Schreml, S., Prantl, L., Franke, R.P., Jung, E.M.}, title={Effect of iodinated contrast media on renal perfusion: A randomized comparison study in pigs using quantitative contrast-enhanced ultrasound (CEUS)}, year={2017}, howpublished = {journal article}, doi = {https://doi.org/10.1038/s41598-017-13253-y}, abstract = {The administration of iodinated contrast media (CM) can cause microcirculatory disorder leading to acute renal dysfunction. In a prospective, randomized investigation two CM (Iodixanol vs Iopromide) were compared in 16 pigs. Each animal received 10 intra-aortal injections (5 ml Iodixanol or 4.32 ml Iopromide). Microcirculation was assessed using contrast-enhanced ultrasound (CEUS) directly on the kidney surface using time-to-peak (TTP) and blood-volume-analysis. Macroscopic observations were documented. Post mortem residual CM distribution in the kidneys was detected using X-ray. TTP was significantly prolonged over the descending vasa recta of the Iopromide group. This coincided with a visible marble-like pattern on the kidney surface occurring in 30 out of 80 Iopromide-injections but in 4 out of 80 Iodixanol-injections (p = 0.007). The blood volume over the entire kidney did not change after Iodixanol-application, but decreased by about 6.1% after Iopromide-application. The regional blood volume in the renal cortex showed a tendency to decrease by about 13.5% (p = 0.094) after Iodixanol-application, and clearly decreased by about 31.7% (p = 0.022) after Iopromide-application. The study revealed a consistent influence of repeated injections of two different CM on the kidney perfusion using three different imaging methods (CEUS analysis, macroscopic observation and X-ray analysis).}, note = {Online available at: \url{https://doi.org/10.1038/s41598-017-13253-y} (DOI). Lamby, P.; Jung, F.; Graf, S.; Schellenberg, L.; Falter, J.; Platz-da-Silva, N.; Schreml, S.; Prantl, L.; Franke, R.; Jung, E.: Effect of iodinated contrast media on renal perfusion: A randomized comparison study in pigs using quantitative contrast-enhanced ultrasound (CEUS). Scientific Reports. 2017. vol. 7, 13125. DOI: 10.1038/s41598-017-13253-y}}