%0 journal article
%@ 1944-8244
%A Yu, L., Hou, Y., Cheng, C., Schlaich, C., Noeske, P.-L.M., Wei, Q., Haag, R.

%D 2017
%J ACS Applied Materials and Interfaces
%N 51
%P 44281-44292 
%R doi:10.1021/acsami.7b13515
%T High-Antifouling Polymer Brush Coatings on Nonpolar Surfaces via Adsorption-Cross-Linking Strategy
%U https://doi.org/10.1021/acsami.7b13515
51 
%X A new “adsorption-cross-linking” technology is presented to generate a highly dense polymer brush coating on various nonpolar substrates, including the most inert and low-energy surfaces of poly(dimethylsiloxane) and poly(tetrafluoroethylene). This prospective surface modification strategy is based on a tailored bifunctional amphiphilic block copolymer with benzophenone units as the hydrophobic anchor/chemical cross-linker and terminal azide groups for in situ postmodification. The resulting polymer brushes exhibited long-term and ultralow protein adsorption and cell adhesion benefiting from the high density and high hydration ability of polyglycerol blocks. The presented antifouling brushes provided a highly stable and robust bioinert background for biospecific adsorption of desired proteins and bacteria after secondary modification with bioactive ligands, e.g., mannose for selective ConA and Escherichia coli binding.