%0 journal article
%@ 1386-0291
%A Kaessmeyer, S., Sehl, J., Khiao In, M., Hiebl, B., Merle, R., Jung, F., Franke, R.P., Plendl, J.

%D 2016
%J Clinical Hemorheology and Microcirculation
%N 3
%P 391-402 
%R doi:10.3233/CH-168119
%T Organotypic soft-tissue co-cultures: Morphological changes in microvascular endothelial tubes after incubation with iodinated contrast media
%U https://doi.org/10.3233/CH-168119
3 
%X RESULTS: In the organotypic soft-tissue co-cultures with fibroblasts, the endothelial cells developed three-dimensional capillary-like structures which expanded via sprouting branches. After incubation with the different CM, the numbers of endothelial tubes (p = 0.001) and their lengths (p = 0.003) were significantly lower after the 5 minutes incubation time, when compared to the 1.5 minutes incubation time. The tubular diameters were significantly reduced after 5 minutes (p < 0.001), when compared to the 1.5 minutes incubation duration. Interestingly, Iomeprol and Iodixanol induced an elongation of the tubular branches during incubation duration of 1.5 minutes (p = 0.015). However, after 5 minutes incubation, the tubular branches were drastically shorter in the presence of Iomeprol and Iodixanol than the tubular branches of the control (p = 0.007).