@misc{dong_a_highly_2016, 
author={Dong, C., Liu, Z., Liu, J., Wu, C., Neumann, F., Wang, H., Schaefer-Korting, M., Kleuser, B., Chang, J., Li, W., Ma, N., Haag, R.},
title={A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging},
year={2016},
howpublished = {journal article},
doi = {https://doi.org/10.1002/adhm.201600212},
abstract = {Considering the critical role of mitochondria in the life and death of cells, non-invasive long-term tracking of mitochondria has attracted considerable interest. However, a high-performance mitochondria-specific labeling probe with high photostability is still lacking. Herein a highly photostable hyperbranched polyglycerol (hPG)-based near-infrared (NIR) quantum dots (QDs) nanoplatform is reported for mitochondria-specific cell imaging. Comprising NIR Zn-Cu-In-S/ZnS QDs as extremely photostable fluorescent labels and alkyl chain (C12)/triphenylphosphonium (TPP)-functionalized hPG derivatives as protective shell, the tailored QDs@hPG-C12/TPP nanoprobe with a hydrodynamic diameter of about 65 nm exhibits NIR fluorescence, excellent biocompatibility, good stability, and mitochondria-targeted ability. Cell uptake experiments demonstrate that QDs@hPG-C12/TPP displays a significantly enhanced uptake in HeLa cells compared to nontargeted QDs@hPG-C12. Further co-localization study indicates that the probe selectively targets mitochondria. Importantly, compared with commercial deep-red mitochondria dyes, QDs@hPG-C12/TPP possesses superior photostability under continuous laser irradiation, indicating great potential for long-term mitochondria labeling and tracking. Moreover, drug-loaded QDs@hPG-C12/TPP display an enhanced tumor cell killing efficacy compared to nontargeted drugs. This work could open the door to the construction of organelle-targeted multifunctional nanoplatforms for precise diagnosis and high-efficient tumor therapy.},
note = {Online available at: \url{https://doi.org/10.1002/adhm.201600212} (DOI). Dong, C.; Liu, Z.; Liu, J.; Wu, C.; Neumann, F.; Wang, H.; Schaefer-Korting, M.; Kleuser, B.; Chang, J.; Li, W.; Ma, N.; Haag, R.: A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging. Advanced Healthcare Materials. 2016. vol. 5, no. 17, 2214-2226. DOI: 10.1002/adhm.201600212}}