@misc{brunacci_influence_of_2017, 
author={Brunacci, N., Wischke, C., Naolou, T., Neffe, A.T., Lendlein, A.},
title={Influence of surfactants on depsipeptide submicron particle formation},
year={2017},
howpublished = {journal article},
doi = {https://doi.org/10.1016/j.ejpb.2016.11.011},
abstract = {Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5–20 kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method. In a second set of experiments, sOEG-DAT of Mn = 10 kDa was compared with the commonly employed emulsifiers polyvinylalcohol (PVA), polyoxyethylene (20) sorbitan monolaurate (Tween 20), and D-α-tocopherol polyethylene glycol succinate (VIT E-TPGS) for OBMD particle preparation. sOEG-DAT allowed to systematically change sizes in a range of 300 up to 900 nm with narrow polydispersity, while in the other cases, a lower size range (250–400 nm, PVA; ∼300 nm, Tween 20) or no effective particle formation was observed. The ability of tailoring particle size in a broad range makes sOEG-DAT of particular interest for the formation of oligodepsipeptide particles, which can further be investigated as drug carriers for controlled delivery.},
note = {Online available at: \url{https://doi.org/10.1016/j.ejpb.2016.11.011} (DOI). Brunacci, N.; Wischke, C.; Naolou, T.; Neffe, A.; Lendlein, A.: Influence of surfactants on depsipeptide submicron particle formation. European Journal of Pharmaceutics and Biopharmaceutics. 2017. vol. 116, 61-65. DOI: 10.1016/j.ejpb.2016.11.011}}