%0 journal article
%@ 1742-7061
%A Federico, S., Noechel, U., Loewenberg, C., Lendlein, A., Neffe, A.T.

%D 2016
%J Acta Biomaterialia

%P 1-10 
%R doi:10.1016/j.actbio.2016.04.018
%T Supramolecular hydrogel networks formed by molecular recognition of collagen and a peptide grafted to hyaluronic acid
%U https://doi.org/10.1016/j.actbio.2016.04.018
 
%X The extracellular matrix (ECM) is a nano-structured, highly complex hydrogel, in which the macromolecules are organized primarily by non-covalent interactions. Here, in a biomimetic approach, the decorin-derived collagen-binding peptide LSELRLHNN was grafted to hyaluronic acid (HA) in order to enable the formation of a supramolecular hydrogel network together with collagen. The storage modulus of a mixture of collagen and HA was increased by more than one order of magnitude (G′ = 157 Pa) in the presence of the HA-grafted peptide compared to a mixture of collagen and HA (G′ = 6 Pa). The collagen fibril diameter was decreased, as quantified using electron microscopy, in the presence of the HA-grafted peptide. Here, the peptide mimicked the function of decorin by spatially organizing collagen. The advantage of this approach is that the non-covalent crosslinks between collagen molecules and the HA chains created by the peptide form a reversible and dynamic hydrogel, which could be employed for a diverse range of applications in regenerative medicine.