%0 journal article
%@ 0909-0495
%A Wieland, D.C.F., Haramus, V.M., Zander, T., Krywka, C., Wang, M., Dedinaite, A., Claesson, P.M., Willumeit-Roemer, R.

%D 2016
%J Journal of Synchrotron Radiation
%N 2
%P 480-486 
%R doi:10.1107/S1600577515024856
%T Studying solutions at high shear rates: a dedicated microfluidics setup
%U https://doi.org/10.1107/S1600577515024856
2 
%X The development of a dedicated small-angle X-ray scattering setup for the investigation of complex fluids at different controlled shear conditions is reported. The setup utilizes a microfluidics chip with a narrowing channel. As a consequence, a shear gradient is generated within the channel and the effect of shear rate on structure and interactions is mapped spatially. In a first experiment small-angle X-ray scattering is utilized to investigate highly concentrated protein solutions up to a shear rate of 300000 s-1. These data demonstrate that equilibrium clusters of lysozyme are destabilized at high shear rates.