@misc{chen_baicalin_loaded_2016, 
author={Chen, Y., Minh, L.V., Lui, J., Angelov, B., Drechsler, M., Haramus, V.M., Willumeit-Roemer, R., Zou, A.},
title={Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting},
year={2016},
howpublished = {journal article},
doi = {https://doi.org/10.1016/j.colsurfb.2015.11.018},
abstract = {Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)—targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about −25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0–46.4% and 8.8–10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.},
note = {Online available at: \url{https://doi.org/10.1016/j.colsurfb.2015.11.018} (DOI). Chen, Y.; Minh, L.; Lui, J.; Angelov, B.; Drechsler, M.; Haramus, V.; Willumeit-Roemer, R.; Zou, A.: Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting. Colloids and Surfaces  B. 2016. vol. 140, 74-82. DOI: 10.1016/j.colsurfb.2015.11.018}}