@misc{khan_surface_modification_2015, 
author={Khan, M., Yang, J., Shi, C., Feng, Y., Zhang, W., Gibney, K., Tew, G.N.},
title={Surface Modification of Polycarbonate Urethane with Zwitterionic Polynorbornene via Thiol-ene Click-Reaction to Facilitate Cell Growth and Proliferation},
year={2015},
howpublished = {journal article},
doi = {https://doi.org/10.1002/mame.201500038},
abstract = {Herein, we grafted the zwitterionic polynorbornene onto polycarbonate urethane (PCU) film surface by a convenient route of thiol-ene click-chemistry. The PCU film surface was first treated with hexamethylene-1,6-diisocynate and subsequently with two different thiol agents (l-cysteine and β-marcaptoethanol) in the presence of di-n-butyltin dilaurate (DBTDL) to immobilize sulfhydryl groups onto the surface. Here, DBTDL acted as selective catalyst for the reaction between surface-tethered isocyanates and amine/hydroxyl groups in thiol agents over that of free thiol groups. In the next step, zwitterionic polynorbornene (poly(NSulfoZI)) having functionalizable double bonds was grafted onto these surfaces by photo-initiated thiol-ene click-reaction. The modified surfaces were characterized by water contact angle and XPS analysis. Moreover, the cytocompatibility of these surfaces was investigated by model endothelial cells, EA.hy926, for 1, 3, and 7 d culture times, which showed enhanced cell adhesion and growth. Therefore, the poly(NSulfoZI) functionalized PCU surface using l-cysteine as thiol agent could be a good candidate for tissue engineering material application.},
note = {Online available at: \url{https://doi.org/10.1002/mame.201500038} (DOI). Khan, M.; Yang, J.; Shi, C.; Feng, Y.; Zhang, W.; Gibney, K.; Tew, G.: Surface Modification of Polycarbonate Urethane with Zwitterionic Polynorbornene via Thiol-ene Click-Reaction to Facilitate Cell Growth and Proliferation. Macromolecular Materials and Engineering. 2015. vol. 300, no. 8, 802-809. DOI: 10.1002/mame.201500038}}