%0 journal article
%@ 1549-9634
%A Ostrowski, A.,Nordmeyer, D.,Boreham, A.,Brodwolf, R.,Mundhenk, L.,Fluhr, J.W.,Lademann, J.,Graf, C.,Ruehl, E.,Alexiev, U.,Gruber, A.D.

%D 2014
%J Nanomedicine: Nanotechnology, Biology and Medicine
%N 7
%P 1571-1581 
%R doi:10.1016/j.nano.2014.04.004
%T Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles
%U https://doi.org/10.1016/j.nano.2014.04.004
7 
%X The skin is a potential site of entry for nanoparticles (NP) but the role of disease-associated barrier disturbances on the path and extent of skin penetration of NP remains to be characterized. Silica nanoparticles (SiO2-NP) possess promising potential for various medical applications. Here,,effects of different skin barrier disruptions on the penetration of N-(6-aminohexyl)-aminopropyltrimethoxysilane (AHAPS) functionalized SiO2-NP,were studied. AHAPS-SiO2-NP (55 ± 6 nm diameter)were topically applied on intact, tape stripped or on inflamed skin of SKH1 mice with induced allergic contact dermatitis for one or five consecutive days, respectively. Penetration of AHAPS-SiO2-NP through the skin was not observed regardless of the kind of barrier disruption. However, only after subcutaneous injection, AHAPS-SiO2-NP were incorporated by macrophages and transported to the regional lymph node only. Adverse effects on cells or tissues were not observed. In conclusion, AHAPS-SiO2-NP seemto not cross the normal or perturbed mouse skin.