%0 journal article
%@ 1549-9634
%A Ostrowski, A., Nordmeyer, D., Boreham, A., Brodwolf, R., Mundhenk, L., Fluhr, J.W., Lademann, J., Graf, C., Ruehl, E., Alexiev, U., Gruber, A.D.

%D 2014
%J Nanomedicine: Nanotechnology, Biology and Medicine
%N 7
%P 1571-1581 
%R doi:10.1016/j.nano.2014.04.004
%T Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles
%U https://doi.org/10.1016/j.nano.2014.04.004
7 
%X were studied. AHAPS-SiO2-NP (55 ± 6 nm diameter)were topically applied on intact, tape stripped or on inflamed skin of SKH1 mice with induced allergic contact dermatitis for one or five consecutive days, respectively. Penetration of AHAPS-SiO2-NP through the skin was not observed regardless of the kind of barrier disruption. However, only after subcutaneous injection, AHAPS-SiO2-NP were incorporated by macrophages and transported to the regional lymph node only. Adverse effects on cells or tissues were not observed. In conclusion, AHAPS-SiO2-NP seemto not cross the normal or perturbed mouse skin.