@misc{zhao_mixture_of_2014, author={Zhao, S., Yang, X., Haramus, V.M., Handge, U.A., Luthringer, B., Zhao, L., Salamon, G., Willumeit, R., Zou, A., Fan, S.}, title={Mixture of Nonionic/Ionic Surfactants for the Formulation of Nanostructured Lipid Carriers: Effects on Physical Properties}, year={2014}, howpublished = {journal article}, doi = {https://doi.org/10.1021/la501141m}, abstract = {The objective of the present work was to investigate the effects of the mixture of nonionic/ionic surfactants on nanostructured lipid carriers (NLCs). Nonionic surfactant (polyethylene–poly(propylene glycol), Pluronic F68) and ionic surfactant (octenylsuccinic acid modified gum arabic, GA-OSA) were chosen as emulsifier for NLCs. The NLCs systems, which were composed of lipid matrix, modified 4-dedimethylaminosancycline (CMT-8), and various emulsifier agents, were characterized with dynamic light scattering (DLS), high performance liquid chromatography (HPLC), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), in vitro release, and phagocytosis assay. This mixture of nonionic/ionic surfactants showed significant effects on physical properties including particle size, polydispersity index (PDI), entrapment efficiency, and particle morphology. Compared with single stabilizer, this mixed nonionic/ionic surfactant system provided NLCs with better drug carrier properties including prolonged release profile and low phagocytosis by phagocyte. We expect that these explorations can provide a new strategy for the development of lipid nanoparticles as drug delivery.}, note = {Online available at: \url{https://doi.org/10.1021/la501141m} (DOI). Zhao, S.; Yang, X.; Haramus, V.; Handge, U.; Luthringer, B.; Zhao, L.; Salamon, G.; Willumeit, R.; Zou, A.; Fan, S.: Mixture of Nonionic/Ionic Surfactants for the Formulation of Nanostructured Lipid Carriers: Effects on Physical Properties. Langmuir. 2014. vol. 30, no. 23, 6920-6928. DOI: 10.1021/la501141m}}