%0 journal article
%@ 1742-7061
%A Riyaz, S.,Sun, Y.,Helmholz, H.,Penate-Medina, T.,Penate-Medina, O.,Wiese, B.,Will, O.,Albaraghtheh, T.,Farhad, H.M.,Hövener, J.B.,Glüer, C.C.,Willumeit-Römer, R.

%D 2024
%J Acta Biomaterialia
%N 
%P  
%R doi:10.1016/j.actbio.2024.06.040
%T Inflammatory response toward a Mg-based metallic biomaterial implanted in a rat femur fracture model
%U https://doi.org/10.1016/j.actbio.2024.06.040
 
%X The immune system plays an important role in fracture healing, by modulating the pro-inflammatory and anti-inflammatory responses occurring instantly upon injury. An imbalance in these responses can lead to adverse outcomes, such as non-union of fractures. Implants are used to support and stabilize complex fractures. Biodegradable metallic implants offer the potential to avoid a second surgery for implant removal, unlike non-degradable implants. However, considering our dynamic immune system it is important to conduct in-depth studies on the immune response to these implants in living systems. In this study, we investigated the immune response to Mg and Mg-10Gd in vivo in a rat femur fracture model with external fixation. In vivo imaging using liposomal formulations was used to monitor the fluorescence-related inflammation over time. We combine ex vivo methods with our in vivo study to evaluate and understand the systemic and local effects of the implants on the immune response. We observed no significant local or systemic effects in the Mg-10Gd implanted group compared to the SHAM and Mg implanted groups over time. Our findings suggest that Mg-10Gd is a more compatible implant material than Mg, with no adverse effects observed in the early phase of fracture healing during our 4-week study.