%0 journal article %@ 2304-6732 %A Longo, E.,Alj, D.,Batenburg, J.,de La Rochefoucauld, O.,Herzog, C.,Greving, I.,Li, Y.,Lyubomirskiy, M.,Falch, K.V.,Estrela, P.,Flenner, S.,Viganò, N.,Fajardo, M.,Zeitoun, P. %D 2022 %J Photonics %N 2 %P 98 %R doi:10.3390/photonics9020098 %T Flexible Plenoptic X-ray Microscopy %U https://doi.org/10.3390/photonics9020098 2 %X X-ray computed tomography (CT) is an invaluable technique for generating three-dimensional (3D) images of inert or living specimens. X-ray CT is used in many scientific, industrial, and societal fields. Compared to conventional 2D X-ray imaging, CT requires longer acquisition times because up to several thousand projections are required for reconstructing a single high-resolution 3D volume. Plenoptic imaging—an emerging technology in visible light field photography—highlights the potential of capturing quasi-3D information with a single exposure. Here, we show the first demonstration of a flexible plenoptic microscope operating with hard X-rays; it is used to computationally reconstruct images at different depths along the optical axis. The experimental results are consistent with the expected axial refocusing, precision, and spatial resolution. Thus, this proof-of-concept experiment opens the horizons to quasi-3D X-ray imaging, without sample rotation, with spatial resolution of a few hundred nanometres.