%0 journal article
%@ 1386-0291
%A Gerk, U.,Mrowietz, C.,Sternitzky, R.,Franke, R.P.,Spitzer, S.G.,Jung, F.

%D 2016
%J Clinical Hemorheology and Microcirculation
%N 3
%P 297-304 
%R doi:10.3233/CH-168101
%T Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study
%U https://doi.org/10.3233/CH-168101
3 
%X Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography.,The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line.,VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%.