%0 journal article
%@ 0743-7463
%A Degen, P.,Wielandt, D.C.F.,Stroetges, C.

%D 2015
%J Langmuir
%N 43
%P 11851-11857 
%R doi:10.1021/acs.langmuir.5b02702
%T Mixed Layers of Nonionic Dendritic Amphiphiles and DPPC at the Water Surface
%U https://doi.org/10.1021/acs.langmuir.5b02702
43 
%X Nonionic dendritic amphiphiles that self-assemble into defined supramolecular aggregates are useful for the efficient solubilization of active agents, for example, in drug delivery. We investigated a new class of dendritic amphiphiles based on a hydrophilic polyol dendron head connected to a two-chain hydrophobic block. In analogy to phospholipids, these molecules form well-organized layers in bulk (vesicles) or at the water surface (Langmuir monolayer). The actual study focuses on the phase behavior and microscopic structure of mixed Langmuir layers of theses dendritic amphiphiles with the well-known phospholipid DPPC. The combination of surface pressure area isotherms with X-ray grazing incident diffraction and Brewster angle microscopy gives us information on the phase behavior of the mixed monolayers and the orientation of the amphiphiles inside the condensed domains with molecular resolution. We could prove that the dendritic generation and, by this, the headgroup size of the amphiphilic molecules have a significant influence on their interaction with DPPC at the air–water interface. Thus, our findings are important for the understanding of mixed lipid membranes in general as well as for the preparation of artificial membranes and vesicles with adjustable properties, e.g., their drug delivery potential.