%0 journal article
%@ 1386-0291
%A Jung, F.,Braune, S.,Lendlein, A.

%D 2013
%J Clinical Hemorheology and Microcirculation
%N 1-2
%P 97-115 
%R doi:10.3233/CH-2012-1579
%T Haemocompatibility testing of biomaterials using human platelets
%U https://doi.org/10.3233/CH-2012-1579
1-2 
%X Cardiovascular implants are increasingly important in regenerative medicine. To improve the safety and function of blood-contacting implants a major need exists for new polymer-based biomaterials that avoid adverse reactions, particularly thrombotic events. This review is aimed to summarize the multi-stepped and interlinked processes leading to a thrombus growth on body foreign surfaces: protein adsorption, platelet adhesion accompanied by activation and spreading and the release of substances of various organelles activating other neighboured platelets (and the plasmatic coagulation) leading to the formation of a plug of platelets and, finally, to a thrombus.