%0 journal article
%@ 1934-8630
%A Golub, M.,Lott, D.,Watkins, E.B.,Haramus, V.M.,Luthringer, B.,Stoermer, M.,Schreyer, A.,Willumeit, R.

%D 2013
%J Biointerphases
%N 1
%P 21 
%R doi:10.1186/1559-4106-8-21
%T X-ray and neutron investigation of self-assembled lipid layers on a titanium surface
%U https://doi.org/10.1186/1559-4106-8-21
1 
%X Titanium is the most widely preferred metal material for bone reconstruction in orthopedics and dentistry. To improve its biological performance, various coatings can be applied. In this investigation, a biomimetic coating on a model implant surface was studied in X-ray and neutron reflectivity experiments to probe the quality of this coating, which is only few nanometers thick. Titanium was deposited on polished silicon surfaces using a magnetron sputtering technique. To improve the lipid coating’s stability, a stronger van der Waals interaction was first created between the implant surface and the biomimetic coating by adding a phosphonic acid (n-octadecylphosphonic acid – OPA) monolayer onto the surfaces. Then, three monolayers of POPE (phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine) were transferred using the Langmuir-Blodgett (LB) and Langmuir-Schaefer (LS) techniques. The analysis of X-ray and neutron specular reflectivity data shows that OPA molecules cover the model implant surface completely and that approximately 50% coverage of POPE can be achieved by LB and LS transfer.