%0 journal article
%@ 1292-8941
%A Filippov, S.K.,Porsch, B.,Sergeeva, O.Y.,Olifirenko, A.S.,Lesnichin, S.B.,Domnina, N.S.,Komarova, E.A.,Lezov, A.V.,Haramus, V.M.,Walterova, Z.,Stepanek, P.

%D 2011
%J The European Physical Journal  E
%N 
%P 123 
%R doi:10.1140/epje/i2011-11123-7
%T Molecular properties of hybrid macromolecular antioxidants: Dextran hydrophobically modified by sterically hindered phenols
%U https://doi.org/10.1140/epje/i2011-11123-7
 
%X The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity—polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule.,An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate,macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant,groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure.