@misc{luo_degradation_adaptability_2023, 
author={Luo, X.,Li, M.,Cai, H.,Yang, S.,Hao, L.,Ebel, T.,Helmholz, H.,Huang, B.,Wang, X.},
title={Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications.},
year={2023},
howpublished = {journal article},
doi = {https://doi.org/10.1021/acsabm.3c00710},
abstract = {Semisolid powder molding was used to prepare the medical Mg–6Zn alloy; in order to further improve its degradation adaptability, 0.5 and 1 wt % Mn were added. Then, the effect of the forming temperature (540, 560, 580, and 600 °C) on the in vitro degradation behavior of the prepared Mg–6Zn–xMn (x = 0.5, 1 wt %) was analyzed, and the optimized alloy was obtained. Finally, the biocompatibility and in vivo degradation performance of the optimized and Mn-free alloys were evaluated. Importantly, single-photon emission tomographic imaging (SPECT/CT) was first applied to monitor the in vivo degradation process. The results show that the corrosion mechanism of the Mn-free alloy is microgalvanic corrosion control with corrosive pitting. After adding Mn, the in vitro degradation rate decreases by half (0.17 ± 0.01 mm/year) as the forming temperature increases to 600 °C, and Mg–6Zn–1Mn prepared at 600 °C is the optimized alloy. Mn addition improves the corrosion product film protection and discontinuous secondary phases, and thus, the corrosion mechanism is changed to corrosive pitting control. Additionally, semisolid powder molding is an easy method to prepare alloys with low average pore interconnectivity (<10%), which is helpful for slowing down the degradation rate. The Mn-containing alloy has better biocompatibility, with a cytotoxicity of grade 0–1, due to its lower degradation rate. The in vivo corrosion rate of the Mn-free alloy is 0.19 mm/year after 28 days of implantation, which was precisely detected by SPECT/CT in real-time. The long-term in vivo degradation adaptability of Mn-free and Mn-containing alloys was not correctly presented, which may be due to the unreasonable bone defect model causing implant displacement. However, both of these alloys cause no obvious inflammation and show good healing. In summary, semisolid powder molding is a potentially promising technique to prepare medical Mg alloys, and nuclear imaging is an effective in vivo degradation evaluation method.},
note = {Online available at: \url{https://doi.org/10.1021/acsabm.3c00710} (DOI). Luo, X.; Li, M.; Cai, H.; Yang, S.; Hao, L.; Ebel, T.; Helmholz, H.; Huang, B.; Wang, X.: Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications.. ACS Applied Bio Materials. 2023. vol. 6, no. 11, 5515-5530. DOI: 10.1021/acsabm.3c00710}}