@misc{burmeister_surface_grafted_2023, 
author={Burmeister, N.,Zorn, E.,Farooq, A.,Preuss, L.,Vollstedt, C.,Friedrich, T.,Mantel, T.,Scharnagl, N.,Rohnke, M.,Ernst, M.,Wicha, S.G.,Streit, W.R.,Maison, W.},
title={Surface Grafted N-Oxides have Low-Fouling and Antibacterial Properties},
year={2023},
howpublished = {journal article},
doi = {https://doi.org/DOI:10.1002/admi.202300505},
abstract = {Low-fouling materials are often generated by surface zwitterionization with polymers. In this context, poly-N-oxides have recently attracted considerable attention as biomimetic stealth coatings with low protein adsorption. Herein, this study reports that poly-N-oxides can be grafted from plasma-activated plastic base materials. The resulting hydrophilic surfaces have low-fouling properties in bacterial suspensions and suppress the formation of biofilms. Moreover, efficient antibacterial activity against Gram-negative and Gram-positive bacteria caused by release of reactive oxygen species is observed. The latter effect is specific for polymeric N-oxides and is most likely triggered by a reductive activation of the N-oxide functionality in the presence of bacteria. In contrast to other zwitterionic polymers, N-oxides combine thus low-fouling (stealth) properties with antibacterial activity. The bioactive N-oxide groups can be regenerated after use by common oxidative disinfectants. Poly-N-oxides are thus attractive antibacterial coatings for many base materials with a unique combined mechanism of action.},
note = {Online available at: \url{https://doi.org/DOI:10.1002/admi.202300505} (DOI). Burmeister, N.; Zorn, E.; Farooq, A.; Preuss, L.; Vollstedt, C.; Friedrich, T.; Mantel, T.; Scharnagl, N.; Rohnke, M.; Ernst, M.; Wicha, S.; Streit, W.; Maison, W.: Surface Grafted N-Oxides have Low-Fouling and Antibacterial Properties. Advanced Materials Interfaces. 2023. vol. 10, no. 35, 2300505. DOI: DOI:10.1002/admi.202300505}}