@misc{xu_periodic_thermomechanical_2021, 
author={Xu, X.,Nie, Y.,Wang, W.,Ma, N.,Lendlein, A.},
title={Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells},
year={2021},
howpublished = {journal article},
doi = {https://doi.org/10.1557/s43579-021-00049-5},
abstract = {Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.},
note = {Online available at: \url{https://doi.org/10.1557/s43579-021-00049-5} (DOI). Xu, X.; Nie, Y.; Wang, W.; Ma, N.; Lendlein, A.: Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells. MRS Communications. 2021. vol. 11, no. 4, 425-431. DOI: 10.1557/s43579-021-00049-5}}