@misc{stervbo_age_dependent_2017, 
author={Stervbo, U.,Pohlmann, D.,Baron, U.,Bozzetti, C.,Juerchott, K.,Maelzer, J.N.,Nienen, M.,Olek, S.,roch, T.,Schulz, A.R.,Warth, S.,Neumann, A.,Thiel, A.,Gruetzkau, A.,Babel, N.},
title={Age dependent differences in the kinetics of GammaDelta T cells after influenza vaccination},
year={2017},
howpublished = {journal article},
doi = {https://doi.org/10.1371/journal.pone.0181161},
abstract = {Immunosenescence is a hallmark of the aging immune system and is considered the main cause of a reduced vaccine efficacy in the elderly. Although γδ T cells can become activated by recombinant influenza hemagglutinin, their age-related immunocompetence during a virus-induced immune response has so far not been investigated. In this study we evaluate the kinetics of γδ T cells after vaccination with the trivalent 2011/2012 northern hemisphere seasonal influenza vaccine. We applied multi-parametric flow cytometry to a cohort of 21 young (19–30 years) and 23 elderly (53–67 years) healthy individuals. Activated and proliferating γδ T cells, as identified by CD38 and Ki67 expression, were quantified on the days 0, 3, 7, 10, 14, 17, and 21. We observed a significantly lower number of activated and proliferating γδ T cells at baseline and following vaccination in elderly as compared to young individuals. The kinetics changes of activated γδ T cells were much stronger in the young, while corresponding changes in the elderly occurred slower. In addition, we observed an association between day 21 HAI titers of influenza A and the frequencies of Ki67+ γδ T cells at day 7 in the young. In conclusion, aging induces alterations of the γδ T cell response that might have negative implications for vaccination efficacy.},
note = {Online available at: \url{https://doi.org/10.1371/journal.pone.0181161} (DOI). Stervbo, U.; Pohlmann, D.; Baron, U.; Bozzetti, C.; Juerchott, K.; Maelzer, J.; Nienen, M.; Olek, S.; roch, T.; Schulz, A.; Warth, S.; Neumann, A.; Thiel, A.; Gruetzkau, A.; Babel, N.: Age dependent differences in the kinetics of GammaDelta T cells after influenza vaccination. PLoS One. 2017. vol. 12, no. 7, e0181161. DOI: 10.1371/journal.pone.0181161}}