@misc{riabtseva_functional_micelles_2016, 
author={Riabtseva, A.,Mitina, N.,Grytsyna, I.,Boiko, N.,Haramus, V.M.,Stryhanyuk, H.,Stoika, R.,Zaichenko, A.},
title={Functional micelles formed by branched polymeric surfactants: Synthesis, characteristics, and application as nanoreactors and carriers},
year={2016},
howpublished = {journal article},
doi = {https://doi.org/10.1016/j.eurpolymj.2016.01.006},
abstract = {Branched polymeric surfactants composed of grafted non-ionic polyethylene glycol (PEG) and anionic polyelectrolyte chains were synthesized via radical polymerization initiated by the comb-like PEG-containing polyperoxide. Above definite concentration in solution, these surfactants form micelle-like structures (MLS). The MLS formed by branched polymeric molecules are of larger size in comparison with size of MLS formed by the initial PEG-containing polyperoxide that is caused mainly by different mechanism of their self-organization and morphology of formed MLS. The availability of grafted polyelectrolyte chains in the MLS provides a possibility of their use as the containers for immobilization of bio-active substances and nucleation of the inorganic nanoparticles, as well as formation of their stable colloidal systems in water in a wide pH range. Noticeable compaction and narrowed size distribution of the MLS were revealed after immobilization of doxorubicin (Dox) molecules or Fe2O3 nanocrystals. MLS-based systems were used for delivery of Dox and maghemite particles at treatment of tumor cells. Both MLS-based formulations of Dox and Fe2O3 were efficiently engulfed by rat glioma C6 cells. A significant (10 times) decrease in the effective therapeutic dose of Dox was found when this drug was delivered by a MLS-based formulation of Dox. That effect might be explained by a specific structure and functionality of the novel carrier used for immobilization of drug that should be delivered to target cells.},
note = {Online available at: \url{https://doi.org/10.1016/j.eurpolymj.2016.01.006} (DOI). Riabtseva, A.; Mitina, N.; Grytsyna, I.; Boiko, N.; Haramus, V.; Stryhanyuk, H.; Stoika, R.; Zaichenko, A.: Functional micelles formed by branched polymeric surfactants: Synthesis, characteristics, and application as nanoreactors and carriers. European Polymer Journal. 2016. vol. 75, 406-422. DOI: 10.1016/j.eurpolymj.2016.01.006}}