@misc{schwerk_adiposederived_human_2015, 
author={Schwerk, A.,Altschueler, J.,Roch, M.,Gossen, M.,Winter, C.,Berg, J.,Kurtz, A.,Akyuez, L.,Steiner, B.},
title={Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease},
year={2015},
howpublished = {journal article},
doi = {https://doi.org/10.2217/RME.15.17},
abstract = {Background: Mesenchymal stem cells (MSC) are easily harvested, and possess anti-inflammatory and trophic properties. Furthermore, MSC promote neuroprotection and neurogenesis, which could greatly benefit neurodegenerative disorders, such as Parkinson's disease. Methods: MSC were transplanted one week after 6-hydroxydopamine lesioning and effects were evaluated after 6 months. Results: MSC localized around the substantia nigra and the arachnoid mater, expressing pericyte and endothelial markers. MSC protected dopamine levels and upregulated peripheral anti-inflammatory cytokines. Furthermore, adipose-derived MSC increased neurogenesis in hippocampal and subventricular regions, and boosted memory functioning. Conclusion: Considering that hyposmia and loss of memory function are two major nonmotor symptoms in Parkinson's disease, transplants with modulatory effects on the hippocampus and subventricular zone could provide a disease-modifying therapy.},
note = {Online available at: \url{https://doi.org/10.2217/RME.15.17} (DOI). Schwerk, A.; Altschueler, J.; Roch, M.; Gossen, M.; Winter, C.; Berg, J.; Kurtz, A.; Akyuez, L.; Steiner, B.: Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. Regenerative Medicine. 2015. vol. 10, no. 4, 431-446. DOI: 10.2217/RME.15.17}}