@misc{melnikova_effect_of_2014, author={Melnikova, L.,Petrenko, V.I.,Avdeev, M.V.,Haramus, V.M.,Almasy, L.,Ivankov, O.I.,Bulavin, L.A.,Mitroova, Z.,Kopcansky, P.}, title={Effect of iron oxide loading on magnetoferritin structure in solution as revealed by SAXS and SANS}, year={2014}, howpublished = {journal article}, doi = {https://doi.org/10.1016/j.colsurfb.2014.08.032}, abstract = {Synthetic biological macromolecule of magnetoferritin containing an iron oxide core inside a protein shell (apoferritin) is prepared with different content of iron. Its structure in aqueous solution is analysed by small-angle synchrotron X-ray (SAXS) and neutron (SANS) scattering. The loading factor (LF) defined as the average number of iron atoms per protein is varied up to LF = 800. With an increase of the LF, the scattering curves exhibit a relative increase in the total scattered intensity, a partial smearing and a shift of the match point in the SANS contrast variation data. The analysis shows an increase in the polydispersity of the proteins and a corresponding effective increase in the relative content of magnetic material against the protein moiety of the shell with the LF growth. At LFs above ∼150, the apoferritin shell undergoes structural changes, which is strongly indicative of the fact that the shell stability is affected by iron oxide presence.}, note = {Online available at: \url{https://doi.org/10.1016/j.colsurfb.2014.08.032} (DOI). Melnikova, L.; Petrenko, V.; Avdeev, M.; Haramus, V.; Almasy, L.; Ivankov, O.; Bulavin, L.; Mitroova, Z.; Kopcansky, P.: Effect of iron oxide loading on magnetoferritin structure in solution as revealed by SAXS and SANS. Colloids and Surfaces B. 2014. vol. 123, 82-88. DOI: 10.1016/j.colsurfb.2014.08.032}}