@misc{sztrokay_assessment_of_2013, 
author={Sztrokay, A.,Herzen, J.,Auweter, S.D.,Liebhardt, S.,Mayr, D.,Willner, M.,Hahn, D.,Zanette, I.,Weitkamp, T.,Hellerhoff, K.,Pfeiffer, F.,Reiser, M.F.,Bamberg, F.},
title={Assessment of grating-based X-ray phase-contrast CT for differentiation of invasive ductal carcinoma and ductal carcinoma in situ in an experimental ex vivo set-up},
year={2013},
howpublished = {journal article},
doi = {https://doi.org/10.1007/s00330-012-2592-1},
abstract = {Objective,Limited contrast between healthy and tumour tissue is a limiting factor in mammography and CT of the breast. Phase-contrast computed tomography (PC-CT) provides improved soft-tissue contrast compared with absorption-based techniques. In this study, we assessed the technical feasibility of grating-based PC-CT imaging of the breast for characterisation of ductal carcinoma in situ (DCIS).,Methods,Grating-based PC-CT was performed on one breast specimen containing an invasive ductal carcinoma and DCIS using monochromatic radiation of 23 keV. Phase-contrast and absorption-based images were compared qualitatively and quantitatively with histopathology in a blinded fashion.,Results,Grating-based PC-CT showed improved differentiation of soft-tissue components. Circular structures of high phase-shift contrast corresponding to the walls of the dilated ductuli of the DCIS were visualised with a contrast-to-noise ratio (CNR) of 9.6 using PC-CT but were not detectable on absorption-based images (CNR = 0.27). The high phase-shift structures of the dilated ductuli were identifiable in the PC-CT volume data set allowing for 3D characterisation of DCIS.,Conclusions,Our results indicate that unlike conventional CT, grating-based PC-CT may allow the differentiation between invasive carcinoma and intraductal carcinoma and healthy breast tissue and provide 3D visualisation of DCIS.},
note = {Online available at: \url{https://doi.org/10.1007/s00330-012-2592-1} (DOI). Sztrokay, A.; Herzen, J.; Auweter, S.; Liebhardt, S.; Mayr, D.; Willner, M.; Hahn, D.; Zanette, I.; Weitkamp, T.; Hellerhoff, K.; Pfeiffer, F.; Reiser, M.; Bamberg, F.: Assessment of grating-based X-ray phase-contrast CT for differentiation of invasive ductal carcinoma and ductal carcinoma in situ in an experimental ex vivo set-up. European Radiology. 2013. vol. 23, no. 2, 381-387. DOI: 10.1007/s00330-012-2592-1}}