@misc{angelova_smallangle_xray_2012, author={Angelova, A.,Angelov, B.,Haramus, V.M.,Couvreur, P.,Lesieur, S.}, title={Small-Angle X-ray Scattering Investigations of Biomolecular Confinement, Loading, and Release from Liquid-Crystalline Nanochannel Assemblies}, year={2012}, howpublished = {journal article}, doi = {https://doi.org/10.1021/jz2014727}, abstract = {This Perspective explores the recent progress made by means of small-angle scattering methods in structural studies of phase transitions in amphiphilic liquid-crystalline systems with nanochannel architectures and outlines some future directions in the area of hierarchically organized and stimuli-responsive nanochanneled assemblies involving biomolecules. Time-resolved small-angle X-ray scattering investigations using synchrotron radiation enable monitoring of the structural dynamics, the modulation of the nanochannel hydration, as well as the key changes in the soft matter liquid-crystalline organization upon,stimuli-induced phase transitions. They permit establishing of the inner nanostructure transformation kinetics and determination of the precise sizes of the hydrophobic,membraneous compartments and the aqueous channel diameters in self-assembled network architectures. Time-resolved structural studies accelerate novel biomedical,,pharmaceutical, and nanotechnology applications of nanochannel soft materials by providing better control of DNA, peptide and protein nanoconfinement, and release from,diverse stimuli-responsive nanocarrier systems.}, note = {Online available at: \url{https://doi.org/10.1021/jz2014727} (DOI). Angelova, A.; Angelov, B.; Haramus, V.; Couvreur, P.; Lesieur, S.: Small-Angle X-ray Scattering Investigations of Biomolecular Confinement, Loading, and Release from Liquid-Crystalline Nanochannel Assemblies. The Journal of Physical Chemistry Letters. 2012. vol. 3, no. 3, 445-457. DOI: 10.1021/jz2014727}}